![]() ![]() ![]() Normal human RBCs are biconcave-shaped discs of about eight µm in diameter and two µm in thickness, and they can undergo passive deformations while maintaining mechanical stability during the microcirculation process. The limitations and drawbacks of each technology are addressed and future prospects are discussed. Lastly, organs on chips, multi-organ chips, and drug discovery involving single RBC are described. Microfluidics based RBC microarrays, sorting/counting and trapping techniques (including acoustic, dielectrophoretic, hydrodynamic, magnetic, and optical techniques) are also reviewed. ![]() This article critically reviews the current state-of-the-art and recent advances of microfluidics for single RBC analyses, including integrated sensors and microfluidic platforms for microscopic/tomographic/spectroscopic single RBC analyses, trapping arrays (including bifurcating channels), dielectrophoretic and agglutination/aggregation studies, as well as clinical implications covering cancer, sepsis, prenatal, and Sickle Cell diseases. Researchers in this field have highlighted the vast potential in developing micro devices for industrial and academia usages, including lab-on-a-chip and organ-on-a-chip systems. The utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted great interests in recent years to filter, trap, analyze, and release single erythrocytes for various applications. ![]()
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